Summary:
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Grey Sloan Memorial returns amidst a crisis with new episodes streaming on Hulu the day after airing.
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Season 22 premieres on Oct. 9, focusing on survival after a hospital explosion with 18 episodes planned.
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Returning cast members include Pompeo, Wilson, Pickens Jr., and more, with new episodes airing weekly on ABC.
Grey Sloan Memorial is back in crisis mode. Season 22 of Grey’s Anatomy officially premieres Thursday, Oct. 9 at 10 p.m. ET on ABC, with new episodes streaming on Hulu the next day. The long-running medical drama returns after last season’s shocking hospital explosion, and this time, survival is only half the battle.
When does ‘Grey’s Anatomy’ Season 22 premiere?
The new season kicks off Thursday, Oct. 9, with the premiere episode titled “Only the Strong Survive.” The story picks up seconds after the explosion that tore through Grey Sloan Memorial. Showrunner Meg Marinis told TV Insider the opener “focuses on who’s OK, who’s not, and what survival looks like when the hospital itself is barely standing.”
Episodes will air weekly on ABC every Thursday at 10 p.m. ET, then hit Hulu on Fridays.
How many episodes will Season 22 have?
ABC confirmed Grey’s Anatomy Season 22 will feature 18 episodes. The second episode, “We Built This City,” marks a major milestone: the show’s 450th episode.
Marinis teased to Shondaland that the creative team plans to honor the show’s legacy with a nostalgic moment “that celebrates how far Meredith and the hospital have come.”
When do new episodes drop?
Following the premiere, episodes will release weekly through mid-November, when the show is expected to go on hiatus before returning in early 2026.
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The current lineup includes:
- Oct. 9 – “Only the Strong Survive”
- Oct. 16 – “We Built This City” (Episode 450)
- Oct. 23 – Episode 3
- Oct. 30 – Episode 4
- Nov. 6 – Episode 5
- Nov. 13 – Episode 6
Who’s in the cast of ‘Grey’s Anatomy’ Season 22?
The returning cast includes:
- Ellen Pompeo as Dr. Meredith Grey
- Chandra Wilson as Miranda Bailey
- James Pickens Jr. as Richard Webber
- Kevin McKidd as Owen Hunt
- Kim Raver as Teddy Altman
- Camilla Luddington as Jo Wilson
- Caterina Scorsone as Amelia Shepherd
- Jason George as Ben Warren
- Chris Carmack as Atticus “Link” Lincoln
- Scott Speedman as Nick Marsh
- Anthony Hill as Winston Ndugu
- Alexis Floyd as Simone Griffith
- Harry Shum Jr. as Benson Kwan
- Adelaide Kane as Jules Millin
Pompeo, who scaled back her on-screen role in Season 19, will appear in seven episodes this season while continuing to narrate and serve as an executive producer.
After last season’s explosive finale, Grey Sloan faces both emotional and physical wreckage. According to ABC’s synopsis, the doctors “fight to save not only their patients’ lives but also their own.”
Marinis hinted that the season will explore recovery, resilience, and rebuilding—both for the hospital and its people. “Being a trauma center means you can’t just shut down,” she told Shondaland. “But when your OR is gone, how do you keep saving lives?”
Where to stream ‘Grey’s Anatomy’
New episodes stream the day after airing on Hulu, while past seasons (1–21) are available on both Hulu and Netflix.
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